Optimality in cellular storage via the Pontryagin Maximum Principle

Optimality in cellular storage via the Pontryagin Maximum Principle

We study an optimal control problem arising from a resource allocation problem in cellular metabolism. A minimalistic model that describes the production of enzymatic vs. non-enzymatic biomass components from a single nutrient source is introduced. The basic growth modes with this model are linear growth, where only the non-enzymatic component is produced, and exponential growth with only enzym...

The Pontryagin Maximum Principle

Theorem (PontryaginMaximum Principle). Suppose a final time T and controlstate pair (û, x̂) on [τ, T ] give the minimum in the problem above; assume that û is piecewise continuous. Then there exist a vector of Lagrange multipliers (λ0, λ) ∈ R × R with λ0 ≥ 0 and a piecewise smooth function p: [τ, T ] → R n such that the function ĥ(t) def =H(t, x̂(t), p(t), û(t)) is piecewise smooth, and one has ̇̂ ...

The Maximum Principle of Pontryagin

Mean-Field Pontryagin Maximum Principle

We derive a Maximum Principle for optimal control problems with constraints given by the coupling of a system of ODEs and a PDE of Vlasov-type. Such problems arise naturally as Γ-limits of optimal control problems subject to ODE constraints, modeling, for instance, external interventions on crowd dynamics. We obtain these first-order optimality conditions in the form of Hamiltonian flows in the...

Contact geometry of the Pontryagin maximum principle

This paper gives a brief contact-geometric account of the Pontryagin maximum principle. We show that key notions in the Pontryagin maximum principle—such as the separating hyperplanes, costate, necessary condition, and normal/abnormal minimizers—have natural contactgeometric interpretations. We then exploit the contact-geometric formulation to give a simple derivation of the transversality cond...